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Improving the photosensitization efficiency represents a critical challenge in photodynamic therapy (PDT) research. While cyanines exhibit potential as photosensitizers (PSs) due to their large extinction coefficients and excellent biocompatibility, the inherent limitations in intersystem crossing severely affect therapeutic efficacy. Herein, we proposed a bottom-up magnetically enhanced photodynamic

Recently, the interest in nonbenzenoid hydrocarbons has resurged, focusing on the replacement of two benzenoid hexagons with a pentagon/heptagon pair, which has led to abundant azulenoid hydrocarbons. For ortho-fused benzenoid hydrocarbons with three or more rings, replacing the three hexagons with a set of two pentagons and one octagon is also possible. Following this concept, we designed pentacyclic

Manganese-based organic-inorganic metal halides (Mn-based OIMHs) scintillators have aroused a research upsurge due to their outstanding photoluminescence performance, low toxicity, and tunable structures. Herein, we demonstrate a molecular engineering strategy that synergistically enhances luminescence efficiency and radiation sensitivity by systematic elongation of branched alkyl chains in phosphonium-based

Harnessing sunlight for photocatalytic overall water splitting offers a sustainable approach to renewable hydrogen production, addressing global energy and environmental challenges. However, the development of efficient and durable photocatalysts remains a significant obstacle. This study introduces the design and performance of a 2D/2D Schottky heterojunction composed of Cu2[CuTCPP] MOF of nanometric

Membrane distillation (MD) is a promising separation technique for producing pure water from brine using low-grade heat. Covalent organic framework (COF) membranes with high porosity and well-ordered pore structure exhibit excellent flux and salt rejection during MD. However, long-term MD operation is often restricted by the inevitable gradual wetting of COF membranes which causes deterioration of

In this paper, we present a novel intracellular strategy for the in situ synthesis of gold–polymer nanocomposites within living bacteria. By transforming Escherichia coli into active nanofactories via intracellular polymerisation-induced self-assembly (iPISA), we achieved precise control over composite architecture. Our findings indicate that bacterial cells play an active role in constructing complex

Supramolecular polymers (SPs) driven by host-guest interactions have seen considerable advancements over the past decade, but the guest species involved are predominantly neutral molecules or cations. Strong and dependable macrocycle-anion interactions for supramolecular polymerization are highly sought after, yet the functionalities of this class of SPs featuring negatively charged backbones remain

Dysregulated lipid metabolism plays a critical role in the pathogenesis of numerous diseases. However, due to the lack of effective solutions, the dynamic monitoring and deep understanding of lipid metabolism in the progression of diseases has remained challenging. Herein, a polarity-sensitive, lipid droplets (LDs)-targeted probe was developed via molecular surgery for spatiotemporal super-resolution

Approximately 40% of marketed drugs exhibit suboptimal pharmacokinetic profiles. Co-crystallization, where pairs of molecules form a multicomponent crystal, constitutes a promising strategy to enhance physicochemical properties without compromising pharmacological activity. However, finding promising co-crystal pairs is resource-intensive, due to the large and diverse range of possible molecular combinations

Scintillators featuring bright and fast-response properties are essential for high-speed and dynamic X-ray imaging. Nevertheless, simultaneously possessing high light yields and fast response remains a significant challenge for most scintillators. Herein, we propose a strategy to achieve the bright and fast-response characteristics of scintillators by leveraging the combined effects of dielectric and

Aqueous Zn-ion batteries (AZIBs) are widely regarded as the ideal candidate for large-scale energy storage systems. However, Zn metal anode has long faced challenges, such as: hydrogen evolution reaction, dendrite growth, surface corrosion. Herein, we report the development of a self-healable and strongly adhesive polymer protective layer for AZIBs, which is achieved by polymerizing a natural small

The development of closed-loop recyclable polymers with comparable performances with commodity plastics remains as a challenge to establish a circular plastic economy. In this contribution, we propose a?precipitation/crystallization driven non-equilibrium ring-opening polymerization of δ-thiovalerolactone (δTVL) to produce high-molecular-weight PTVL in the presence of a strong base/urea binary catalyst

Photocatalysis provides a promising approach to produce green energy, by which the intermittent solar energy can be converted into storable chemical energy. Well-known that the electron transfer rate has great influence on the photocatalytic efficiency. Revealing the influence of electron transfer rate on the photocatalytic efficiency from a molecular level is of great significance but challenge. Herein

Site-selective and divergent functionalizations on saturated alkyl chain at specific unfunctionalized positions is a key challenge in organic chemistry and other related areas and offers unprecedented synthetic opportunities. Herein, a ligand-controlled Ni-catalyzed site-selective and divergent alkyl-alkyl reductive coupling between two different alkyl halides has been developed. Notably, the reaction

Pancreatic cancer (PC) remains difficult to treat due to its dense extracellular matrix (ECM), immunosuppressive tumor microenvironment (TME), and deep-seated anatomy. To address these challenges, we developed IR&ZnPc@LNP-NO, an ultrasound (US)-responsive lipid nanosonosensitizer that synergizes sonodynamic therapy (SDT), chemotherapy, and immunotherapy for orthotopic PC. IR&ZnPc@LNP-NO undergoes three

Increasing the molecular weight of the acceptor is an effective strategy to suppress excessive crystallization and molecular diffusion, thereby addressing morphological challenges in organic solar cells (OSCs). Therefore, designing high-molecular-weight acceptor with well-defined structures is crucial for achieving efficient and stable OSCs?towards commercialization. Herein, we report a calix[8]arene-tethered

Electrochemical CO2 reduction (CO2RR) is a promising method for converting CO2 into valuable chemicals, with formate being a particularly viable product. However, current gas-fed CO2RR systems rely on highly pure CO2 feed gases and are incompatible with point-source CO2 emissions without prior capture and concentration. Bicarbonate electrolysis offers a potential solution by bridging the gap between

Cyclobutane-fused polycyclic scaffolds are structurally interesting cores in natural product synthesis and drug discovery. The construction of these skeletons often requires elaborate synthetic effort and gives low efficiency. We herein demonstrated the divergent construction of various cyclobutane-fused 2D/3D pentacyclic scaffolds by a photocatalytic intermolecular double dearomative cycloaddition

Quasi-two-dimensional (quasi-2D) perovskites have shown great potential in the application of light-emitting diodes (LEDs) due to their large exciton binding energy, tunable bandgaps and solution processability. However, the heavily used spacer cations will cause serious deprotonation reactions in quasi-2D perovskite films, leading to lattice collapse and abundant defect states, which is notorious

The electrocatalytic nitrate reduction reaction (NO3?RR) holds tremendous potential for remediating NO3? pollution in groundwater while enabling clean ammonia (NH3) production. However, most catalysts achieve high conversion efficiency relying on high NO3? concentrations. How to catalyze the NO3?RR with low concentration of NO3? is still a challenge due to the competing hydrogen evolution reaction

Letter to the Editor